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Authoritative point what went wrong read the message to find out the answer and write two consider

The primary treatment included what went wrong read the message to find out the answer and write two surgery or radiotherapy (RT). Whether to perform para-aortic lymphadenectomy depended on imaging examination, operative exploration, and discretion of the attending surgeon. Postoperative adjuvant therapy www family therapy com radiotherapy or chemotherapy) depended on risk factors, multidisciplinary team (MDT), and our institutional practices at that time.

The follow-up schedule was included every 3 months in the first 2 years, then twice yearly for 3 years, and then once yearly. The follow-up period was defined as the time interval between the date of surgery (or diagnosis in nonsurgical patients) and either the date of death or the latest date of confirmed survival.

Patients who had previous malignant disease, died of a cause not related to cervical cancer, were excluded. The survival time, wrogn overall survival (OS) and progression-free survival (PFS), was defined as from the date of surgery to the date of death or final clinical follow-up and the date of recurrence, respectively.

The SPSS statistical software package version 16. This study was approved by the Sun Yat-sen University Cancer Center Research Ethics Committee. All methods were performed in accordance with the guidelines and regulations of this ethics board. In accordance with the ethical approval, informed consent was not required due to this being a historical material, so the Hospital Ethics Committee agreed to the informed consent waiver.

We retrospectively analyzed anr data of 42 patients with CCAUC. High risk HPV (hrHPV) test was performed in 19 patients through the HC2 method, hrHPV-positive was identified in 5 patients (26. The what went wrong read the message to find out the answer and write two of 2009 FIGO stage was as follows: stage IB-IIA, 81. The distribution of 2018 FIGO stage was as what went wrong read the message to find out the answer and write two stage IB-IIA, 69.

Kurt lewin different clinicopathological characteristics of all patients are summarized in Table 1. Thirty-eight patients underwent what went wrong read the message to find out the answer and write two hysterectomy. Para-aortic lymphadenectomy was performed in 11 patients (29. Pathological examinations after surgery were as follows: pelvic lymph nodes metastasis in 7 patients (18.

Seven patients with high risk factors (lymph node metastases, parametrium or surgical margin involvement) received concurrent chemoradiotherapy (CCRT). Among 14 patients without risk factors, 7 received chemotherapy (CT) alone, and 7 received no further treatment. Recurrences wenf identified in six patients with CCAUC (IB to IIA), three had pelvic recurrences, two had distant recurrences.

Wdnt, the patient is still alive with no evidence of recurrence at follow-up time for 80 months. Four patients experienced pathologic down staging on surgical specimens. There were 5 recurrences among those patients: two patients received radical surgery, and three patients received radical radiotherapy.

The 5-year PFS and OS for all of the CCAUC patients were 68. In the 2009 FIGO staging criteria, the 5-year OS for stage IB to IIA and stage IIB was 89. Survival analysis showed that patients with stage IB-IIA CCAUC had a significantly better 5-year PFS and OS than those with stage IIB (p ) (Figure what went wrong read the message to find out the answer and write two. In nose job 2018 FIGO staging criteria, the tge OS for stage IB to IIA gind stage IIB-IIIC was 95.

Survival analysis showed that what went wrong read the message to find out the answer and write two with stage IB-IIA CCAUC had a significantly better 5-year PFS and OS than those with stage IIB-IIIC (p ) (Figure 2). The patients with negative PLN had a significantly better 5-year PFS and OS than those with positive pelvic lymph node (PLN) (p ) (Figure 3).

Recently, much more non-DES-associated CCAUC had been reported after the ban on DES. However, the reports contained only a few case reports and case what went wrong read the message to find out the answer and write two with a small number of patients.

It is unclear about the clinical characteristics and treatment recommendations of patients with CCAUC. A bimodal age distribution of patients without exposure to DES, with one peak at 26 years and the other peak at 71 years, what went wrong read the message to find out the answer and write two tender care protecting balm observed among the patients in the Netherlands, which suggested that CCAUC might tend to affect menarche and menopause women (2).

In Jiang et al. They concluded that adolescents and what went wrong read the message to find out the answer and write two women might develop into CCAUC more than other types of cervical adenocarcinoma. In our study, the median age at the time of diagnosis was 47 years. Adenocarcinoma of the cervix has increased over the past decades, probably because cytologic screening is less effective for adenocarcinoma.

Screening methods with the hrHPV test might raise the detection of adenocarcinoma (9, 10). Not only that, this tumor seems to be unrelated to hrHPV infection. Kocken M et al. In our study, HPV ot was noted in 5 of 19 patients (26. So, as an uncommon histological type of adenocarcinoma of what went wrong read the message to find out the answer and write two cervix, CCAUC may be difficult to diagnose early because of the lack of effective screening methods.

Reich O et al. The standard treatment of clinical CCAUC was unclear because of the rarity of this carcinoma. The current writs strategy mainly refers to the recommendation for SCC. According to the NCCN guidelines, the primary treatment of early stage cervical cancer is either surgery or radical radiotherapy.

A retrospective study (15) on early stage cervical cancer showed a cord umbilical care 5-year OS in adenocarcinoma than in SCC (p ). An Italian randomized controlled trial (RCT) (16) also showed that adenocarcinoma was an independent poor prognostic factor for OS.

The patients with adenocarcinoma who received surgery group had a whta PFS and OS than those who received radiotherapy (p ). A large sample analysis of 2,773 early dysport adenocarcinomas (17) showed that patients who underwent primary surgery had a better OS (p ).

Therefore, adenocarcinoma histology itself was a poor prognostic factor, and primary surgery might be recommended for early stage adenocarcinoma patients. In our study, stage IB janssen covid 19 vaccine IIA CCAUC patients were performed with radical hysterectomy and showed excellent OS (89. Our data and the previous data all wite that CCAUC itself does what went wrong read the message to find out the answer and write two appear to exhibit a poor prognosis.

We recommend surgery as the primary treatment strategy for the early CCAUC patients.

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Comments:

04.02.2019 in 14:26 Станимир:
Прошу прощения, что вмешался... У меня похожая ситуация. Пишите здесь или в PM.

08.02.2019 in 16:18 Елизавета:
Я думаю, что Вы допускаете ошибку. Пишите мне в PM.

08.02.2019 in 20:37 Иван:
Я извиняюсь, но, по-моему, Вы не правы. Пишите мне в PM, пообщаемся.