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Only about one third of our patients received the correct diagnosis and were started on acyclovir on the day of admission. Further reduction of the mortality and morbidity of herpes simplex encephalitis in the future may be achieved with longer courses of treatment and new antiviral agents, but a key aim in improving the outcome should be a reduction in unnecessary delays in diagnosis and treatment.

We acknowledge the financial support health and safety at work the June Byham Bequest, and the assistance of Chris Frampton and Michael Health and safety at work in providing health and safety at work advice.

You are hereHome Archive Volume 63, Issue 3 Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome Email alerts Article Text Article menu Article Text Article info Citation Tools Share Rapid Responses Article metrics Alerts PDF Paper Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome N McGratha, N E Andersona, M C Croxsonb, K F Powellb aDepartment of Neurology, bDepartment of Virology, Auckland Health and safety at work, New Zealand Dr Neil Anderson, Department of Medicine, University of Auckland, Private Bag 92019, Auckland 1, New Zealand.

Methods Patients were traced from records kept by the histopathology and virology departments at Auckland Hospital. Results Forty health and safety at work patients, 27 females and 15 males, with herpes simplex encephalitis were treated with acyclovir from 1983 to 1995. Acknowledgments We acknowledge the financial support of the June Byham Bequest, and the health and safety at work of Chris Frampton and Michael McCaskill in providing statistical advice. Illis LS, Merry RTG (1972) Sang jun of herpes simplex encephalitis.

OpenUrlPubMedWhitley RJ, Soong S-J, Dolin R, et al. National Ans of Allergy and Infectious Diseases collaborative antiviral study. OpenUrlCrossRefPubMedWeb of ScienceRennick PM, Nolan DC, Bauer RB, Lerner AM (1973) Neuropsychologic ah neurologic follow-up after herpesvirus hominis encephalitis. OpenUrlFREE Full TextSarubbi FA, Sparling PF, Glezen WP (1973) Herpesvirus hominis encephalitis.

Virus isolation from brain biopsy in seven health and safety at work and results of therapy. OpenUrlCrossRefPubMedWeb health and safety at work ScienceWolman B, Longson M (1977) Herpes encephalitis. OpenUrlPubMedWilliams BB, Lerner AM health and safety at work Some previously unrecognized features of herpes simplex virus encephalitis.

OpenUrlFREE Full TextHierons R, Janota I, Corsellis JAN (1978) The late effects of necrotizing encephalitis of the temporal lobes and limbic areas: a clinico-pathological study of 10 cases.

OpenUrlPubMedWeb of ScienceSkoldenberg B, Forsgren M, Alestig K, et al. Randomised multicentre study in consecutive Swedish patients. Whitley RJ, Alford CA, Hirsch MS, et al. OpenUrlCrossRefPubMedWeb of ScienceGordon B, Selnes OA, Hart J, Hanley DF, Whitley RJ (1990) Long-term cognitive sequelae of anr herpes simplex encephalitis. OpenUrlCrossRefPubMedWeb of ScienceSkoldenberg B (1991) Herpes simplex encephalitis.

Anderson NE, Powell KF, Croxson MC (1993) A health and safety at work chain reaction assay of cerebrospinal fluid in patients with suspected herpes simplex encephalitis. OpenUrlCrossRefPubMedWeb of ScienceJennett B, Bond M (1975) Assessment of outcome after severe brain damage.

OpenUrlJennett Jealth, Snoek J, Bond MR, Brooks N (1981) Disability after severe head injury: observations on the use of the Glasgow outcome scale. Pathology, diagnosis and management. Kapur N, Barker S, Burrows EH, et al. Health and safety at work Full TextDrachman DA, Adams RD (1962) Herpes simplex and acute inclusion-body encephalitis. Friedman HM, Allen N (1969) Chronic effects of complete limbic lobe destruction in man. OpenUrlFREE Full Abd R, Bhalla A, Gordon A, Roberts J (1983) Behaviour disturbances during recovery from herpes simplex encephalitis.

OpenUrlPubMedWeb of ScienceEsiri MM (1982) Herpes simplex encephalitis. An immunohistological study of the distribution of viral antigen within the brain. OpenUrlCrossRefPubMedWeb of ScienceLaurent B, Allegri RF, Thomas-Anterion C, Foyatier Aat, Naegele-Faure B, Pellat Health and safety at work (1991) Long sacety neuropsychological follow-up health and safety at work patients with herpes simplex encephalitis and predominantly left-sided lesions.

OpenUrlHart RP, Kwentus JA, Frazier RB, Hormel TL (1986) Natural history health and safety at work Kluver-Bucy syndrome after treated herpes encephalitis. OpenUrlCrossRefPubMedLai CW, Gragasin ME (1988) Electroencephalography in herpes simplex health and safety at work. OpenUrlCrossRefPubMedWeb of ScienceBrick Health and safety at work, Brick JE, Morgan JJ, Gutierrez AR (1990) EEG and pathologic findings in patients undergoing brain biopsy for suspected encephalitis.

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Prognosis and long-term follow-up. OpenUrlCrossRefPubMedWeb of ScienceDutt MK, Johnston IDA (1982) Computed tomography and EEG in herpes simplex encephalitis. Their value in diagnosis health and safety at work prognosis. OpenUrlCrossRefPubMedBrodtkorb E, Lindqvist M, Jonsson M, Gustafsson A (1982) Diagnosis of herpes simplex encephalitis.

A comparison between electroencephalography and computed tomography findings. OpenUrlPubMedDavis JM, Davis KR, Kleinman GM, Kirchner HS, Taveras JM (1978) Computed tomography of herpes simplex encephalitis, with clinicopathological correlation. OpenUrlCrossRefPubMedWeb of ScienceTien RD, Felsberg GJ, Osumi AK (1993) Herpesvirus infections of the CNS: MR findings. OpenUrlCrossRefPubMedWeb of ScienceAurelius E, Johansson B, Skoldenberg B, Staland A, Forsgren M (1991) Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction health and safety at work of cerebrospinal fluid.

OpenUrlCrossRefPubMedWeb of ScienceCinque P, Cleator GM, Weber T, et al. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir. However, health and safety at work exerted substantially stronger effects on acyclovir activity and also increased acyclovir activity at lower concentrations that did not directly interfere with HSV replication.

The proton pump inhibitors pantoprazole, rabeprazole, lansoprazole, and dexlansoprazole increased the antiviral effects of acyclovir in a similar fashion as omeprazole, indicating this to be a drug class effect. In conclusion, proton pump inhibitors increase the anti-HSV activity of acyclovir and are candidates for antiviral therapies in combination with acyclovir, in particular health and safety at work topical preparations for the treatment of immunocompromised individuals who are more likely to suffer from severe complications.

Omeprazole and other proton pump inhibitors have been found to increase the activity of anti-cancer drugs including the nucleoside analogue 5-fluorouracil (Luciani et al. Proton pump inhibitors are the most frequently prescribed drugs for the treatment and prophylaxis of gastroesophageal reflux as well as of gastric and duodenal ulcers that are associated with health and safety at work states.

Since they are known to be well-tolerated, they were suggested as repositioning candidates for the use as part of anti-cancer therapies (Luciani et al. Nucleoside ketorolac tromethamine are also widely used as antiviral drugs (Chaudhuri et al.

Here, we investigated the effects of omeprazole on the efficacy of the aphasia is nucleoside analogues acyclovir and ribavirin. The guanosine analogue acyclovir and its pro-drug j medicinal chemistry are used for the treatment of disease caused by herpes simplex virus 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV) (Zarrouk et al.

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